26th APRIL 2024

British man tests first personalised melanoma vaccine.

An important trial of the world's first "personalised" mRNA vaccine against the deadliest form of skin cancer - melanoma - is now under way in the UK.

Steve Young, 52, from Stevenage, Herts, who had a melanoma growth cut out of his scalp last August, is one of the first patients to try the shot.

It is designed to help his immune system recognise and wipe out any remaining cancerous cells.

And hopefully, that means his cancer will not return.

The jab, mRNA-4157 (V940), uses the same technology as current Covid vaccines and is being tested in final-stage Phase III trials.

University College London Hospitals (UCLH) doctors are giving it alongside another drug, pembrolizumab or Keytruda, that also helps the immune system kill cancer cells.

Genetic signature

The combined treatment, made by Moderna and Merck Sharp and Dohme (MSD), is not yet available routinely on the NHS, outside of clinical trials.

Experts in some other countries, including Australia, are also trying it on patients, to gather more evidence and see whether it should be rolled out more widely.

The vaccine is personalised - meaning the make-up of it is changed to suit the individual patient.

It is created to match the unique genetic signature of the patient's own tumour and works by instructing the body to make proteins or antibodies that attack markers or antigens found only on those cancer cells.

'Custom built'

UCLH investigator Dr Heather Shaw said the jab had the potential to cure people with melanoma and was being tested in other cancers - lung, bladder and kidney tumours.

"This is one of the most exciting things we've seen in a really long time," she said.

"It is absolutely custom built for the patient - you couldn't give this to the next patient in the line because you wouldn't expect it to work.

"It's truly personalised.

"These things are hugely technical and finely generated for the patient."

'Really excited'

The UK part of the international trial aims to recruit at least 60-70 patients across eight centres, including in London, Manchester, Edinburgh and Leeds.

Mr Young is having his treatment in London.

He said: "I'm really, really excited.

"This is my best chance at stopping the cancer in its tracks."

He said hearing about the study had "really triggered my geek radar".

Mr Young had a lump on his scalp for many years before realising the growth was cancer.

He said being diagnosed was a "massive shock".

"I literally spent two weeks just thinking 'this is it'," he said.

"My dad died of emphysema when he was 57 and I actually thought 'I'm going to die younger than my dad'."

Common signs of melanoma include:

  • a new abnormal mole

  • an existing mole that seems to be growing or changing

  • a change to a previous patch of normal skin

The earlier a melanoma is picked up, the easier it is to treat and the more likely treatment is to be successful.

Phase II trial data, published in December, found that people with serious high-risk melanomas who received the jab alongside the immunotherapy Keytruda were almost half (49%) as likely to die or have their cancer come back after three years than those who were given only the drug.

Dr Shaw said there was real hope the therapy could be a "gamechanger", particularly as it appeared to have "relatively tolerable side effects".

These include tiredness and a sore arm when the jab was given, she said, adding that for the majority of patients it appeared no worse than having a flu or Covid vaccine.


8th APRIL 2024

The dangerous rise of #sunbeds. Skin Cancer UK demands change to outdated sunbed legislation – calling for warning signs on sunbeds, similar to cigarettes, as TikTok sees surge in sunbed searches reach a blistering 718 million views(1).

14 years ago today, the Government introduced the Sunbed Regulation Act and banned their use by under-18s.  However, sunbeds still kill approximately 100 people each year and recent TikTok search data shows this number is likely to rise with many Brits unaware of the life- threatening danger they pose.

Using a sunbed increases the risk of skin cancer, and 46 new melanoma cases are diagnosed each day in the UK, a rise of 32% over the last decade.  With melanoma skin cancer rates projected to Using a sunbed increases the risk of skin cancer, and 46 new melanoma cases are diagnosed each day in the UK, a rise of 32% over the last decade.  With melanoma skin cancer rates projected to rise by 9% in the UK between 2023–2025 and 2038–2040, predictions suggest there could be around 26,500 new cases of melanoma skin cancer every year by 2038-2040 then (2).

Much of this growth is fueled by social media, with over 200M TikTok searches for #sunbed in the last 12 months. The Sunbed Legislation Act came into play before social media gained such influence, and that’s why Skin Cancer UK is launching today’s mission to get the Government to update the law and make warning signs mandatory, with a powerful video which shows just how harmful UV rays are. 

Much of the upsurge in trips to the tanning salon is due to the rise of ‘nostalgia’ trends, where old school habits are popularised by a younger generation. The desire to caption #sunbed, a genre of content in its own right, is driving TikTokers to film the process for millions.

On TikTok alone, #sunbed boasts over 718 million views (3), with videos including tanning cream and nasal spray reviews, viral hacks for a deeper tan, ‘GRWM’ style videos for the tanning salon, tips for sunbed newbies and even creators sharing alternative tips for sunbeds, such as using them to whiten teeth.

This trend was solidified by Kim Kardashian’s participation in the popular ‘I’m…of course I….’ craze, in which the queen of social media reclines in a tanning bed, stating “I’m Kim Kardashian, of course I have a tanning bed – and a red-light bed – in the office.” She later went on to defend herself, claiming sunbeds help her psoriasis – but with 9.7million followers on the platform, and over 38.7million views on that video alone, the impact of normalising sunbeds on a platform saturated with 10-19-year-olds is inevitable.  Early use of sunbeds is particularly dangerous, with sunbed use before 35 increasing the risk of skin cancer by almost 60%.  Sunbeds are already banned in Australia, Brazil, and Iran. 

That was certainly the case for Ross Robinson, who noticed a lesion on his back after extensive sunbed use, he said “The rise in use of sunbeds is alarming and of deep concern. We need to keep having this discussion so that more information is available, and people can be educated on how sunbed use dramatically increases the risk of developing melanoma which is the deadliest form of skin cancer. Our skin is the body’s largest organ and when we tan it’s our body’s reaction to being attacked by UV rays, moderate exposure to sunlight is healthy but consistent exposure from sunbeds is deadly. This is why I am in support of Melanoma Law and updating the current sunbed regulation”.

Sunbeds can emit up to 15x more UVA than the sun, which led The World Health Organisation to declare sunbeds as dangerous as smoking and place their use into the highest risk level for cancer alongside cigarettes, alcohol, and asbestos (4).

To get involved and support a change in the Sunbeds (Regulation) Act 2010 law, click on the link and sign the petition here and show further support on social media using the official campaign hashtag.
#themelanomalaw

(1) https://countik.com/tiktok-hashtag-generator
(2) Cancer Research UK. Melanoma skin cancer statistics. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/melanoma-skin-cancer#heading-Zero. Last accessed: 10 April 2024
(3) https://countik.com/tiktok-hashtag-generator
(4) IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Radiation. 2012; 100: 7–303


27th JANUARY 2024

Sarah Ferguson diagnosed with skin cancer just months after breast cancer treatment

Sarah, Duchess of York, has been diagnosed with skin cancer, just six months after being treated for breast cancer.

She was diagnosed with malignant melanoma, a form of skin cancer, after having several moles removed - with one of those identified as being cancerous.

A spokesman for the duchess, 64, said she remained in "good spirits" despite the diagnosis.

She is due to undergo further investigations to ensure the cancer has been caught in the early stages.

"Following her diagnosis with an early form of breast cancer this summer, Sarah, Duchess of York has now been diagnosed with malignant melanoma," her spokesman said.

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"Her dermatologist asked that several moles were removed and analysed at the same time as the duchess was undergoing reconstructive surgery following her mastectomy, and one of these has been identified as cancerous.

"She is undergoing further investigations to ensure that this has been caught in the early stages.

"Clearly, another diagnosis so soon after treatment for breast cancer has been distressing, but the duchess remains in good spirits."

The spokesman said the duchess wanted to express her gratitude to the medical team - believed to be from King Edward VII Hospital in London - who had supported her through the process.

He said the duchess's experience also underlined "the importance of checking the size, shape, colour and texture and emergence of new moles that can be a sign of melanoma".

Duchess 'proud of mastectomy'

Last year, the duchess, the former wife of Prince Andrew, Duke of York, underwent an eight-hour single mastectomy operation and reconstruction after discovering she had an early form of breast cancer during a routine mammogram.

She previously said she had no symptoms and almost missed her appointment until her sister convinced her to go.

In a TV interview in December, she said she was "proud" of her mastectomy and described it as a "badge of office".

She also described the moment she decided to have her breast removed as she drove away from the Royal Free Hospital in Hampstead, north London, and began searching for information about the disease online.

The news of her skin cancer diagnosis comes after it was announced that the King is to attend hospital next week to be treated for an enlarged prostate.

It came less than two hours after it was announced that his daughter-in-law, Kate, Princess of Wales, had undergone abdominal surgery and will remain in hospital for up to two weeks.

What is malignant melanoma?

Malignant melanoma is a type of skin cancer that can spread to other areas of the body.

According to the NHS, the main cause of melanoma is ultraviolet light, which comes from the sun, as well as from sunbeds.

Factors such as age, a family history of skin cancer, and having pale skin or a large number of moles can increase your chances of developing melanoma.

A new mole or a change in an existing mole may be signs of melanoma, as well as large moles, or those with uneven shapes, or a mixture of colours.

The NHS advises people to contact their GP if they notice a new mole or changes to existing moles, including if one becomes itchy, painful or inflamed.

People who notice a dark area under a nail that has not been caused by an injury should also contact their GP.